Negroamaro. Today we'll stay in southern Italy but move away from the heel and into the toe of the boot to end up in Calabria.
Historically, Calabria was known as Enotria, which means "land of wine." I'm unclear, though, whether it was because of the wine produced there or whether it was because it was named for a guy named Oenotrus who, as the legend has it, left Greece to settle there and became its first king. Whatever the case happens to be, vineyards in Calabria date back to ancient Greek times and many of the grapes grown in the region have been grown there in some capacity for the last 3000 years.
One of those grapes is Gaglioppo. Gaglioppo is a somewhat hardy grape, able to survive the hot, dry conditions of Calabria but still susceptible to a few fungal diseases. It's unusual in that it has fairly thick skins but isn't particularly tannic. It was thought for many years that Gaglioppo, like Calabria's first king, was an import from Greece, but recent DNA evidence doesn't seem to support that interpretation. In an article from 2008, a team of researchers found that Gaglioppo (along with a host of other Italian grapes) likely has a parent-offspring relationship with Sangiovese. The writing in that article is pretty dense, but from what I can gather, their DNA analysis seems to indicate that Sangiovese is likely one of the two parents for Gaglioppo, which means that Gaglioppo is likely native to Italy and not a Greek import at all.
A study done in 2010 has confirmed that Gaglioppo is an offspring of Sangiovese. The full parentage of Gaglioppo is Sangiovese x Mantonico Bianco. Source: Cipriani, G. et al. The SSR-based molecular profile of 1005 grapevine (Vitis vinifera L.) accessions uncovers new synonymy and parentages, and reveals a large admixture amongst varieties of different geographic origin. 2010. Theoretical and Applied Genetics. 121: 1569-1585.
Modern day Calabrian wine isn't something that many people get too excited about. As little as 5% of the agricultural land in Calabria is devoted to the vine, and nearly all of it (up to 90%) is used for red wine production. Of that production, only about 4% is classified as DOC wine with the rest ending up as IGT, table wine or fodder for the distillery. There are 12 DOC regions (no DOCGs), of which the most well known is Cirò, which may not be saying much. The Oxford Companion to Wine's entire entry on Cirò reads: "the only DOC of any quantitative significance in the southern Italian region of Calabria." Wines made in Cirò must contain at least 95% Gaglioppo with up to 5% of the white grapes Greco and/or Trebbiano allowed.